Tertiary structure of proteins
This structure is maintained thanks to the bonds that occur between the -R radicals of the different amino acids, located at positions very far from the peptide chain.
- Hydrogen bridge bonds between nonionic polar groups in which there are partial charges in their side chain.
- Electrostatic attractions, ionic bonds between R groups of acidic amino acids (negatively charged, -COO-) and basic amino acids (positively charged, -NH3+).
- Hydrophobic attractions and Van der Waals forces between aliphatic radicals of apolar amino acid side chains.
- Disulfide bridges, covalent bonds between two thiol groups (-SH), corresponding to two cysteines.